Sgo1 as a 'guardian spirit' for preventing colon tumorigenesis

摘要

High-fidelity chromosome segregation during both mitosis and meiosis is essential for the propagation and inheritance of stable genomes. Defects in these fundamental processes promote aberrant chromosome segregation, which, in the absence of cell death, produces aneuploid progeny. In somatic cells, aneuploidy is a putative cancer-promoting event. In germ cells, aneuploidy can reduce reproductive fertility and promote the accumulation of trisomies, such as those associated with Down, Patau or Edward syndromes.