IL-3 up-regulates and activates human eosinophil CD32 and alpha M beta 2 integrin causing degranulation

摘要

Background Eosinophils contribute to the pathogenesis of multiple diseases, including asthma. Treatment with antibodies targeting IL-5 or IL-5 receptor a reduces the frequency of asthma exacerbations. Eosinophil receptors for IL-5 share a common a-chain with IL-3 and GM-CSF receptors. We recently reported that IL-3 is more potent than IL-5 or GMCSF in maintaining the ERK/p90S6K/RPS6 ribosome-directed signaling pathway, leading to increased protein translation.