New disguises for an old channel: MaxiK channel beta-subunits

摘要

Ca2+-activated K+ channels of large conductance (MaxiK or BK channels) control a large variety of physiological processes, including smooth muscle tone, neurosecretion, and hearing. Despite being coded by a single gene (Slowpoke), the diversity of MaxiK channels is great. Regulatory beta-subunits, splicing, and metabolic regulation create this diversity fundamental to the adequate function of many tissues.