Does L to D-amino acid substitution trigger helix -> sheet conformations in collagen like peptides adsorbed to surfaces?

摘要

The present work reports on the structural order, self assembling behaviour and the role in adsorption to hydrophilic or hydrophobic solid surfaces of modified sequence from the triple helical peptide model of the collagenase cleavage site in type I collagen (Uniprot accession number P02452 residues from 935 to 970) using (D)Ala and (D)ile substitutions as given in the models below: