Our expert panel highlights the most important research articles across the spectrum of topics relevant to the field of neuropsychiatry

摘要

Multiple lines of research suggest that: depression is associated with enhanced sensitivity to negative (punishing) stimuli and diminished sensitivity to positive (rewarding) stimuli across many facets of learning, memory and cognition. In this study, investigators used functional MRI (fMRI) to compare the hemody-namic response to a novel reversal learning paradigm between individuals with unmedicated major depressive disorder (MDD; n = 13) and age-matched healthy controls (n =12). Participants were presented with stimuli (a scene and a face), one of which was associated with reward (a green smiling face) and another with punishment (a red sad face). Participants were asked to predict whether a highlighted stimulus would lead to reward or punishment while learning these associations by trial and error during an acquisition block.