Effect of irradiation on lung metastasis of VX2 carcinoma in maxillary sinus of rabbit

摘要

Effects of local single irradiation on lung metastasis of VX2 carcinoma transplanted in maxillary sinus of rabbits were evaluated. When an inadequate irradiation for complete regression was given, the rate of pulmonary metastases in irradiated groups was remarkably increased compared with non-irradiated one, although tumor growths in irradiated ones were apt to be inhibited corresponding to the given dose. Three parameters detected in the study related to general conditions were not so significantly different among the groups although those in irradiated groups were apt to be worse than those in control. Histologically most remarkable difference between in control and irradiated groups was stromal respose. However, on the question of whether stromal response could react as a diffensive or promotive mechanisms against tumor metastases, further studies would be needed including analysis of infiltrative cells.