Clinical and polysomnographic characteristics in 20 north Indian patients with narcolepsy: A seven-year experience from a neurology service

摘要

We read with great interest the article by Gupta et al. However, we would like to discuss some issues of the study, hi this study, polysomnography recordings of leg movements were recorded only from the right leg. Unfortunately, this would cause periodic leg movement (PLM) index to be lower. American Academy of Sleep Medicine (AASM) recommends scientists to record leg movements from both tibialis anterior muscles.Also, in the article, there is no information about the PLM index. But in patients with narcolepsy, especially the ones with cataplexy, PML syndrome may coexist and this could contribute to the increase of arousal index. Studies show that the prevalence of narcolepsy within the first-degree relatives of narcolepsy patients is high. For this reason, the first-degree relatives of narcolepsy patients are also recommended to be scanned for narcolepsy. Hypocretin-1 level in the cerebrospinal fluid (CSF) is one of the diagnostic criteria for narcolepsy. Its level is recommended as deterrnining the diagnostic criteria, especially in narcolepsy patients with cataplexy and in patients who have multiple sleep latency test (MSLT) difficult to interpret.