Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults

摘要

The development of coronary atherosclerosis is a lifelong process that begins as early as childhood.1 We assessed whether contemporary polygenic scores (PGSs) for coronary artery disease (CAD) or for risk factors of CAD can predict the presence of raised coronary plaque among adolescents and young adults examined in the PDAY study (Pathobiological Determinants of Atherosclerosis in Youth) involving 1 5 laboratories that conducted autopsies on 2876 people aged 15 to 34 years dying of external causes between 1987 and 1 994.1