A New Bithiophene from the Root of Echinops grijsii

摘要

A new bithiophene, 5-(4-hydroxy-3-methoxy-l-butyny)-2,2'-bithiophene (1), and sixteen known thiophenes: 2-(3,4-dihydroxybut-l-ynyl)-5-(penta-1,3-diynyl)thiophene (2), alpha-terthienyl (3), 5-(3,4-dihydroxybut-l-ynyl)-2,2'-bithiophene (4), 5-acetyl-2,2'-bithiophene (5), 5-formyl-2,2'-bithiophene (6), methyl 2,2'-bithiophene-5-carboxylate (7), 5-(but-3-en-l-ynyl)-2,2'-bithiophene (8), 5-(4-isovaleroyloxybut-l-ynyl)-2,2'-bithiophene (9), cardopatine (10), isocardopatine (11), 5-(3-hydroxy-4-isovaleroyloxybut-l-ynyl)-2,2'-bithiophene (12), 5-(3-hydroxymethy1-3-isovaleroyloxyprop-1-ynyl)-2,2'-bithiophene (13), 5-(4-hydroxy-l-butynyl)-2,2'-bithiophene (14), 5-(4-acetoxy-l-butynl)-2,2'-bithiophene (15), 2,2'-bithiophene-5-carboxylic acid (16) and 2-(4-hydroxybut-lynyl)-5-(penta-1,3-diynyl)thiophene (17) were isolated from the roots of Echinops grijish Hance. Among them, compounds 6, 7 and 16 were isolated from a natural source for the first time. Compounds 2, 4 and 14 exhibited significant anti-inflammatory activity against nitrite of LPS-stimulated production in the RAW 264.7 cell line.