Two new compounds from gorgonian-associated fungus aspergillus sp.

摘要

One new γ-lactone derivative 5-hydroxy-3-isopropyl-4-methoxyfuranone (1) and one new lactam derivative dehydrated-marinamide (2), along with two known compounds marinamide (3) and marinamide methyl ester (4) were isolated from the fermentation broth of the marine gorgonian-associated fungus Aspergillus sp. SCSGAF0093. Their structures were elucidated on the basis of spectroscopic and spectrometric analysis. Compound 1 showed significant toxicity to brine shrimp (Artemia salina) with a median lethal concentration (LC50) of 1.25 μM, and 3 inhibited protein tyrosine phosphatase 1B (PTPlB) with a half maximal inhibitory concentration (IC50) of 23.3 μg/mL.