Synthesis of 2,6'-Dioxo-1',5',6',7'-tetrahydrospiroindoline-3,4'-pyrazolo3,4-6pyridine-5'-carbonitriles via a One-Pot, Three-Component Reaction in Water

摘要

A one-pot, three-component condensation reaction of an isatin, aminopyrazole, and alkyl cyanoacetate in water to give 2,6'-dioxo-l',5',6',7'-tetrahydrospiroindoline-3,4'-pyrazolo3,4-bpyridine-5'-carbonitrile with good yields, at 90 °C, using a Et3N as catalyst, is described.