Continuing menace of rifampicin resistant tuberculosis in Rims Hospital, Imphal, Manipur

摘要

© 2021 JK Practitioner. All rights reserved.Background: India has set an ambitious goal of tuberculosis elimination by 2025 which is going to be limited by a large burden of multidrug resistant tuberculosis (MDR-TB). Resistance to rifampicin is a surrogate marker of MDR-TB. Detection of rpoB gene mutation by Cartridge Based Nucleic Acid Amplification Test (CB-NAAT) is used to detect rifampicin resistance. Objective: To determine the burden of rifampicin resistant tuberculosis in Regional Institute of Medical Sciences (RIMS) Hospital, Imphal, a tertiary care hospital in Manipur. Method: The study was a cross sectional study conducted on 100 cases of tuberculosis between the age group of 14-80 years visiting Regional Institute of Medical Sciences (RIMS) Hospital, Imphal, a tertiary care centre from September 2018 to December 2019. Samples were subjected to Ziehl-Neelsen (ZN) stain and smear positive samples were then sent for CB-NAAT analysis at Intermediate Reference Laboratory (IRL), Lamphel, Imphal and a part of it was inoculated in Lowenstein Jensen (LJ) medium for culture. Results: Of 100 samples (M=71, F=29), 42 were of grade 1+, 29 were grade 2+ and 29 were grade 3+ on ZN staining. 87(M=64, F=23) showed positive culture growth. Maximum cases of tuberculosis as well as rifampicin resistance were seen in the age group of 41-50 years. 5 males (7) and 2 females (6.9) were resistant to rifampicin respectively. 6(6.4) of newly diagnosed and 1(16.7) of old cases were rifampicin resistant tuberculosis (RR-TB). The total number of rifampicin resistance in our study was 7(7). Conclusion: Although MDR-TB/RR-TB is emerging as a significant threat to tuberculosis control, limited data is available. Hence, the present research work is undertaken to highlight the continuing menace of rifampicin resistant tuberculosis in RIMS Hospital, a tertiary care centre in Manipur. In our study, 7 rifampicin resistance was observed, which is significantly high. This indicates the importance of strengthening the awareness programmes, establishing early diagnosis and administration of correct and prompt treatment.