Furo3,2-hquinoline Derivatives as a Gastric H + /K + -ATPase Inhibitors

摘要

Furo3,2-hquinoline derivatives were synthesized as a gastric H+ /K+ -ATPase inhibitors. The oxycyclization of 7 and 8-positions in quinoline potentiated the inhibitory activity, while no significant changes in biological activity were observed by the variation of substituents in furan ring. The several furo3,2-hquinoline derivatives were worthy of in vivo investigation for their anti-secretory and anti-ulcer activity.