Generation of Hydroxyl Radicals in the Reaction of Ferritin with Hydrogen Peroxide

摘要

Reactive oxygen species (ROS) such as the superoxide anion (O_2~(-·)), hydrogen peroxide (H2O2) and the hydroxyl radical (~·OH) are generated both from endogenous sources such as cellular metabolism or inflammation, and from exogenous sources including molecular oxygen andUV light.ROS are involved in normal cell processes such as cell signaling and proliferation. However, when present in excess amounts, ROS damage cellular biomolecules and have been implicated in the etiology of a broad variety of diseases, including atherosclerosis, diabetes, neurodegenerative diseases, chronic inflammatory disease, and cancer and aging.