Kinetic Resolution of β-Chromenyl-β-Hydroxy Esters for Asymmetric Preparation of Flavene Derivatives

摘要

Functionalized 2H-chromenes are widely distributed in biologically important natural products and pharmaceutical agents. While a variety of synthetic methods for chromene derivatives has become well developed, asymmetric synthetic methods for optically active chromene derivatives remain limited. We describe in this paper our approach for the asymmetric preparation of 2,3-disubstituted chromene derivatives using the kinetic resolution of β-chromenyl-β-hydroxy esters.