A Convenient and Facile Hantzsch Synthesis of Aryl Imidazo 1,2-bIsoxazolyl-N-aryl Thiazol Amines

摘要

The Hantzsch synthesis of novel aryl imidazo1,2-bisoxazolyl-N-aryl thiazol amines 5 analogues were described. Reaction of 3-aminoisoxazole 1 with substituted phenacyl bromides 2 in dry ethanol afforded the corresponding 6-methyl-3-arylimidazo1,2-bisoxazoles 3 in good yields. Compounds 3 on reaction with chloroacetyl chloride in 1,4-dioxane furnished the corresponding 2-chloro-1-(6-methyl-3-arylimidazo1,2-b isoxazol-2-yl)ethanones 4. Compounds 4 on heating with N-aryl thioureas in an oil bath underwent cyclization to afford the title compounds viz., imidazo1,2-b isoxazolyl-N-aryl thiazol amines 5 in moderate to good yields by Hantzsch synthesis.