Syntheses of Phoyunbenes A-D and Thunalbene for their Anti-Inflammatory Evaluation

摘要

Simple and efficient first syntheses of phoyunbenes A-D and thunalbene have been developed using Horner-Wadsworth- Emmons reaction as a key step. Later, their anti-inflammatory effects were investigated in lipopolysaccharide-induced RAW-264.7 macrophages. The results revealed that phoyunbenes A-D and thunalbene showed weak inhibitory activities without cytotoxicity on the production of nitric oxide (NO) which is an important inflammatory mediator.