Adequacy of a hospital-wide standard dose of 7 mg/kg bodyweight gentamicin sufficient to achieve an adequate prophylactic maximum serum concentration (C-max) in burn patients undergoing surgical burn wound treatment

摘要

Introduction: Pharmacokinetics of drugs can be significantly altered in burn patients. The aim of our study was to validate if the current hospital-wide standard dosage of 7 mg/kg total bodyweight gentamicin is sufficient to achieve an adequate prophylactic C-max (C-max >= 20 mg/L).