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ADAPTIVE WALKS AND DISTRIBUTION OF BENEFICIAL FITNESS EFFECTS

机译:自适应步行和有益健身效果的分配

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We study the adaptation dynamics of a maladapted asexual population on rugged fitness landscapes with many local fitness peaks. The distribution of beneficial fitness effects is assumed to belong to one of the three extreme value domains, viz. Weibull, Gumbel, and Fréchet. We work in the strong selection-weak mutation regime in which beneficial mutations fix sequentially, and the population performs an uphill walk on the fitness landscape until a local fitness peak is reached. A striking prediction of our analysis is that the fitness difference between successive steps follows a pattern of diminishing returns in theWeibull domain and accelerating returns in the Fréchet domain, as the initial fitness of the population is increased. These trends are found to be robust with respect to fitness correlations. We believe that this result can be exploited in experiments to determine the extreme value domain of the distribution of beneficial fitness effects. Our work here differs significantly from the previous ones that assume the selection coefficient to be small. On taking large effect mutations into account, we find that the length of the walk shows different qualitative trends from those derived using small selection coefficient approximation
机译:我们研究了在许多当地健身高峰的崎fitness健身环境中适应不良的无性恋人群的动态变化。假定有益健身效果的分布属于三个极值域之一,即。 Weibull,Gumbel和Fréchet。我们在选择弱的强突变机制中工作,在该机制中,有益的突变会顺序修复,并且种群会在健身景观上进行爬坡直到达到局部健身高峰。我们分析的一个显着预测是,随着人口的初始适应度的提高,连续步骤之间的适应度差异会遵循Weibull域收益递减和Fréchet域收益加速的模式。发现这些趋势相对于适应度相关性是鲁棒的。我们认为,可以在实验中利用此结果来确定有益健身效果分布的极值域。我们在这里的工作与先前假设选择系数很小的工作有很大不同。考虑到较大的效应突变,我们发现步行的长度显示出与使用小选择系数近似得出的定性趋势不同的定性趋势

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