Treatment of the CBPP with oxytetracycline long action and experimental transmission of the disease from treated cattle. [French]Original Title Traitement de la peripneumonie contagieuse bovine par l'oxytetracycline longe action et transmission experimentale de la maladie a partir de bovins traites.

摘要

This study evaluated the effect of long-acting oxytetracycline (Oxytetracycline LA) in the treatment of cattle infested with contagious bovine pleuropneumonia (CBPP) and to determine the risk of disease transmission from animals treated. Experimental transmission was conducted by contacting 16 cattle clinically healthy and seronegative vis-a-vis the antibodies against M. mycoides subsp. mycoides Small Colony (MmmSC) 14 cattle naturally infected with the disease and treated with oxytetracycline LA. The experiment lasted 10 months during which all animals were monitored clinically and sampled at regular intervals for laboratory analysis. Post-mortem examinations were performed on all animals to detect lesions characteristic of CBPP and also take samples for laboratory analysis. The treatment of animals infected with oxytetracycline LA clinically cured a large majority of them (12/14). All 14 animals were seroconverted and post-mortem analysis showed the presence of chronic lesions including pulmonary sequestrations in 4 of them; MmmSC was only isolated from these receivers. However the 16 healthy animals in contact with these 14 animals remained clinically healthy throughout the experimental period, at autopsy no lesions characteristic of CBPP has been noted and laboratory tests were negative. The results of this study may have important implications in the control of CBPP in Africa.