Copper-Catalyzed Synthesis of 13-Aminoisoquinolino2,1-aperimidine-12-carboxylates via alpha-Arylation with a High Chemoselectivity

摘要

The alpha-arylation between cyanoacetate and 2-(2-bromophenyl)-1H-perimidine took place first catalyzed by CuI/L-proline in the presence of NaHCO3, and then the amino on perimidine chemoselectively attacked the cyano group to undergo a nucleophilic addition, giving a series of 13-aminoisoquinolino2,1-aperimidine-12-carboxylate derivatives in good yields.