Synthesis of new functionalized imidazo2,1-bthiazoles and thiazolo3,2-apyrimidines

摘要

5-Oxo-5H-1,3thiazolo3,2-apyrimidine-6-carboxylic acid (4), and 6-methylimidazo2,1-bthiazole-5-carboxylic acid (17) were reacted with amines 6a-i by the reaction with oxalyl chloride and N,N-dimethylformamide as a catalyst into primary and secondary amide derivatives 7-14 and 19-22. From compound 24 N,N'-disubstituted ureas 26, 27 and perhydroimidazo1,5-cthiazole 29 derivatives of imidazo2,1-bthiazole were prepared. By nmr analysis of compound 29, the existence of two stereoisomers resulting from both optical, due to centre of chirality at C7'a, and conformational isomerism, due to restricted C5-N6' bond rotation were proved. References: 21