Histamine and TNF-a release by rat peritoneal mast cellsstimulated with trichomonas vaginalis

摘要

Mast cells have been reported to be predominant in the vaginal smears of patients infected with T. vaginalis. In this study, we investigated whether I vaginalis could induce mast cells to migrate and to produce TNF-a and histamine. Rat peritoneal mastcells (RPMC), a primary mast cell, were used for the study T. vaginalis induced an increase in chemotactic migration of the mast cells toward excretory and secretory product (ESP) of T. vaginalis, and the mast cells activated with I vaginalis showed anincreased release of histamine and TNF-a. Therefore, mast cells may be involved in the inflammatory response caused by T. vaginalis.