Reply from G. Cioffi et al.

摘要

We thank Zhong et al. for their careful reading of our paper on left atrial systolic force in asymptomatic aortic stenosis.1 We totally agree on the well-known limitations of Manning's method,2 including that (1) it is empirically based, (2) that measurement of the mitral orifice area and peak A velocity is performed at different levels, and (3) that the mitral annulus may often be more ellipsoid than circular. Regarding the question about timing of the mitral annulus diameter measurement, this was of course taken at the onset of the P-wave on ECG.