An Efficient Synthesis of Pyrido2,3-dpyrimidine Derivatives in Ionic Liquid

摘要

A series of 5,7-diarylpyrido2,3-dpyrimidine-2,4(1H,3H)-diones was synthesized via the reaction of 6-aminopyrimidine-2,4-dione and alpha,beta-unsaturated ketones in ionic liquid without using any catalyst. This protocol has the advantages of easier work-up, milder reaction conditions, high yields, and environmentally benign procedure over traditional methods.