Late-onset partial complex seizures secondary to cortical dysplasia in a patient with maternal vitamin K deficient embryopathy: Comments on the article by Toriello et al. [2013] and first report of the natural history

摘要

TO THE EDITOR: We read with great interest the article "Maternal Vitamin K Deficient Embryopathy: Association with Hyperemesis Gravidarum and Crohn Disease" by Toriello et al. [2013]. We have been following a 16-year-old female with multiple medical issues including chondrodysplasia punctata, Binder phenotype (Fig. 1), brachytelephalangy, partial complex seizures secondary to cortical dysplasia, Chiari Type II malformation, and tethered cord. Her mother had hyperemesis gravidarum requiring partial parenteral therapy and we believe that her constellation of symptoms can be explained by a similar vitamin K deficiency embryopathy. This is the first report outside of infancy of a patient with symptomatic cortical dysplasia as a result of the syndrome.