Synthesis of 2,3,3a,4,5,6-Hexahydrobenzobthiophene-3a-carbaldehydes via a Tandem Reaction of Cyclic beta-Thiocyanatoenals with Electron-Deficient Alkenes Triggered by Fluoride

摘要

New hexahydrobenzobthiophene derivatives 3 were conveniently synthesized by a fluoride-promoted tandem reaction between cyclic -thiocyanatoenals 1 and terminal electron-deficient alkenes 2 in low to moderate yield. The reaction was initiated by -deprotonation and followed by the Michael addition and nucleophilic attack on sulfur center.