SummaryThis study was undertaken to evaluate a method of prospectively estimating appropriate aminophylline infusion rates in acutely ill, hospitalized patients with bronchospasm. Steady-state serum theophylline concentrations (Css), clearances (Cl), and half-lives (t1/2) were estimated by the Chiou method using serum concentrations obtained 1 and 6 h after the start of a constant-rate intravenous aminophylline infusion in 10 male patients averaging 57 years of age. Using an enzyme-multiplied immunoassay (EMITR system for theophylline analysis, pharmacokinetic estimations were excellent forCss(r = 0.9103, p 0.01) andCl(r = 0.9750, p 0.01). The mean estimation errors were 9.4percnt; (range 0.8ndash;21.5) forCssand 12.3percnt; (range 1.3ndash;28.0) forCl. There was no correlation between patient age andCl. This method is useful for rapidly individualizing aminophylline therapy in patients with acute bronchospasm.
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