Evaluation of Intraoperative Radiation Therapy for Incompletely Resected or Recurrent Canine Hemangiopericytomas Seventeen Cases

摘要

The objective of this study was to evaluate conservative surgery and intraoperative radiation therapy (lORT) for incompletely resected or recurrent hemangiopericytoma. Dogs that had been resected at our faculty and diagnosed as incompletely resected or recurrent hemangiopericytoma were studied. Dogs that had previously undergone surgery or had frequent radiotherapy were excluded. Seventeen dogs met these criteria, of which 10 underwent surgery alone (surgery group), and 7 underwent consecutive surgery and lORT (lORT group). After resection of the tumor, an acrylic cone was set to irradiateunderlying tissue and avoid surrounding skin. The tumor bed was irradiated with a 3-MeV electron beam. The median radiation dose was 10 Gy (range, 10-15 Gy). After TORT, the incision was closed in a routine manner. Ten tumors recurred locally, 6 of 10 (60%) of the surgery group and 4 of 7 (57°/o) of the lORT group. Tumor-free survivals were 441 days (range, 183-1,071 days) in the surgery group and 810 days (range, 660-1,576 days) in the lORT group. The lORT group had significantly longer tumor-free survival than the surgery group (p = 0.043). No radiation side effects were detected. Although the recurrence rate was not significantly different with or without lORT, consecutive surgery and lORT may be able to prolong tumor-free survival without radiation side effects.