Altered anomeric specificity of glucose-induced insulin release in rabbits with duct-ligated pancreas

摘要

Ligation of the pancreatic duct in rabbits provokes a decrease in the insulin and glucagon content of the pancreas, and may lead to chronic hyperglycemia. The insulin secretory behavior of the perfused pancreas is perturbed in duct-ligated animals, and this is illustrated in several respects:1.The steady-state insulin output evoked by L-leucine (10mM) is higher in duct-ligated than control rabbits;2.In the presence of the amino acid, the response to D-glucose is characterized by a delayed onset, the absence of an early secretory peak, and a sluggish return towards basal value upon removal of the hexose from the perfusate; and3.Whereas control rabbits display a higher secretory response to α - than β-D-glucose, such is no more the case in duct-ligated rabbit