Summary—A method for estimating bupivacaine concentration in human plasma by capillary gas‐chromatography using solid injection and nitrogen‐specific detection is described. Etidocaine, another anilidetype local anesthetic was used as internal standard and added to the sample before single‐step extraction with diethylether. This method demonstrates high sensitivity (6 ng/ml plasma) and combines selectivity, rapidity, and simplicity. Results of this procedure correlate well with those obtained by an HPLC
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