The effect of allopurinol, a xanthine oxidase inhibitor, on canine experimental ischemic pancreatitis was studied. The animals were divided into nine groups:1.Group 1. Control with pancreatic ischemia;2.Group 2. Received allopurinol once, previous to ischemia;3.Group 3. Received allopurinol once, immediately after ischemia;4.Group 4. Received allopurinol immediately after ischemia and then daily; and5.Groups 5, 6, and 7 were controls for the operation, allopurinol, and its vehicle, respectively;6.Group 8 (pancreatic ischemia) and Group 9 (that received allopurinol after ischemia and daily) were also studied histologically.
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