The Effect of the Reaction Medium on the Coverage Density of C18Chemically Bonded Phase

摘要

A wide-pore silica for HPLC (SBET= 360 m2g#x2212;1, D = 20 nm, Vp= 2.1 cm3g#x2212;1) was silanized with n-octadecyl dimethylchlorosilane in the presence of several base activators. It has been found that the density of bonded octadecyl ligands is not only a function of reaction time and temperature, but also depends upon the structure of the organic base used as reaction activator. The reproducible synthesis of silica bearing more than 4/umol m#x2013;2of octadecyl ligands is described.