Comparative studies on expression of tumor-associated antigens in human and induced pancreatic cancer in syrian hamsters

摘要

The expression of blood-group-related antigens (BGRAs) in experimental primary pancreatic cancer induced byN-nitrosobis(2-oxopropyl)amine (BOP) treatment of Syrian hamsters and homologous subcutaneous transplants of this primary cancer in the cell line, PC-1, established from the primary cancer and intrapancreatic transplanted PC-1 cells were studied by histochemical and biochemical methods. Human primary pancreatic cancer; the human pancreatic cancer cell line, HPAF; and its subclones, CDU and CD18, also were studied on a comparative basis.