Effect of BW12C on mouse tumor response to radiation

摘要

AbstractThe substituted benzaldehyde BW12C has previously been shown to decrease tumor oxygenation. This, in turn, was linked to the drug's ability to alter the affinity of hemoglobin for oxygen and/or to change tumor blood flow. In the present study, the ability of BW12C to modify oxygen‐hemoglobin binding affinity, tumor blood flow, and tumor radiosensitivity was investigated using BALB/c mice with a 3‐methylcholanthrene‐induced rhabdomyosarcoma and WHT mice with a Fib/T tumor. Results for BALB/c mice indicated that BW12C caused an initial decrease in the P50 and in tumor blood flow, which was accompanied by a decrease in the radiosensitivity of the chemically induced rhabdomyosarcoma. When the P50 and tumor blood flow levels returned to normal again, tumor radiosensitivity increased and exceeded that of mice that were not given BW12C. Although BW12C caused a similar pattern of change in WHT mice with respect to oxygen‐hemoglobin binding affinity, the drug had no effect on Fib/T tumor blood flow or radiosensitivity. © 1995 Wiley