The most adequate concentration of glucose in intraocular irrigating solution for the retina was studied electrophysiologically in the pigmented rabbit in vitro. Comparison of b-wave amplitudes demonstrated that glucose at a concentration of 20 m M/l yielded the highest values. A 40 mM/l glucose solution also increased the b-waves but to a lesser extent than did a solution of 20 mM/l. This result might be due to the detrimental effects of osmolarity. However, under hypoxic conditions the amplitudes of the b-wave obtained with 40 mM/l glucose solution was greater than those with 20 mM/l. It thus appears that slight hyperglycemic concentrations might have favorable effects on the ischemic retina.
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