Fibrinogen Limaperiod; A new dysfibrinogenaemia with a highhyphen;molecular-weight alpha;hyphen;chain and effective polymerization

摘要

A patient with transient microhaematuria was studied. Coagulation tests revealed prolonged thrombin and reptilase times concomitant with abnormal fibrin polymerization rate (also abnormal in both parents). In the patient and her parents, the abnormal fibrin polymerization rate was only slightly corrected by addition of calcium ions. The a-chain had a molecular weight higher than normal and there was deficient formation of a-polymers. The molecule showed a more anodal migration than the control. The abnormality described has been classified as Fibrinogen Lima