Highhyphen;Performance Liquid Chromatographic Measurement of Amiodarone and Its Desethyl MetaboliteMethodology and Preliminary Observations

摘要

A high-performance liquid chromatographic technique is described for the measurement of amiodarone and its desethyl metabolite in plasma. Preliminary observations are presented on the concentrations of metabolite found during the early stages of chronic amiodarone therapy. A case history is outlined in which noncompliance during treatment with amiodarone was confirmed by measurement of the ratio of desethylamiodarone to amiodarone concentrations.