Tuberculous meningitis in South African urban adults

摘要

We retrospectively reviewed 56 adults culture- proven tuberculousmeningitis (TBM), investigating clinical signs, cerebrospinal fluid(CSF) findings and outcome. There were 50 patients, aged 18-59 years,39 with and 11 without human immunodeficiency virus (HIV) infection.Six were aged 60 years or older. Neurological signs of TBM in18-59-years-olds were unaffected by HIV serostatus while, compared tothose ≥60 years of age, there were more patients with meningism(86.0/100 vs. 33.3/100; p=0.001) and fewer with seizures (12.0/100 vs50.0/100; p=0.046).