The effect of hydrocortisone or Panax ginseng, and/or a combination of hydrocortisone and Panax gingseng on phytohaemagglutinin (PHA-P)-induced transformation of peripheral blood lymphocytes were studied in 4 normal healthy adult volunteers. Increasing concentrations of Panax ginseng 0.16–1.60 μg ml––/sup>1 caused a dose-related inhibition of PHA-P transformation of lymphocytes. A combination of 500 μg ml––1 hydrocortisone and 0.80 μg ml––1 Panax ginseng produced a greater suppression of PHA-P stimulation than either drug used alone. This suggests that Panax ginseng has a steroid-like effect in vitro, and may have a potentiating effect with hydrocortisone on T-cell-m
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