Fibrosing colonopathy associated with treatment with enteric-coated mesalazine pills.

摘要

Fibrosing colonopathy consists of the appearance of a thickening of the submucous layer of the colon due to proliferation of connective tissue together with a variable amount of fatty tissue. The dense fibrotic proliferation may cause stenosis of the lumen. This condition was first described by Smyth et al in 19941 in cystic fibrosis patients who were given high doses of pancreatic enzymes in the form of pills with an enteric coating of methacrylic acid (Eu-dragit).