What it means to be well and to achieve well-being is fundamental to the human condition. Scholars of many disciplines have attempted to define well-being and to investigate the behavioral and neural correlates of well-being. Despite many decades of inquiry into well-being, much remains unknown. The study of well-being has evolved over time, shifting in focus and methodology. Many recent investigations into well-being have taken a neuroscientific approach to try to bolster understanding of this complex construct. A growing body of literature has directly examined the association between well-being and the brain. The current review synthesizes the extant literature regarding the neural correlates of trait-like well-being (i.e., the propensity to live according to one's true nature). Although reported associations between well-being and the brain varied, some notable patterns were evidenced in the literature. In particular, the strongest and most consistent association emerged between well-being and the anterior cingulate cortex. In addition, patterns of association between well-being and the orbitofrontal cortex, posterior cingulate cortex, superior temporal gyrus, and thalamus emerged. These regions largely comprise the salience and default mode networks, suggesting a possible relationship between well-being and brain networks involved in the integration of relevant and significant stimuli. Various methodological concerns are addressed and recommendations for future research are discussed.
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