Changes in the Electrochemical Potential Difference for HCO3‐‐between Blood and Cerebrospinal Fluid and in Cerebrospinal Fluid Lactate Concentration during Isocarbic Hypoxia1

摘要

AbstractThe changes in csf HCO3‐ and lactatewere followed in dogs whose arterial pH, Pco2, and HCO3‐‐ were kept constant during 6 hrs hypoxia or normoxia. The results confirm that hypoxia causes a lowering of HCO3‐csf. We believe it is reasonable to assume that an increased anaerobic glycolysis in the brain is responsible for titrating HCO3‐‐out of csf during isocarbic hypoxia although the lactate concentration in csf increased only about one third as much as the HCO3‐‐ decreased. The action of hypoxia on HCO3‐ esf is expressed in terms of its effect on the electrochemical potential difference for HCO3‐‐between mean capillary