Prevalence of Adverse Drug Reactions to Highly Active Antiretro-viral Therapy (HAART) among HIV Positive Patients in Imam Khomeini Hospital of Tehran, Iran

摘要

Objective: The present study assessed the prevalence of adverse drug reactions (ADRs) among HIV positive patients taking antiretroviral therapy referred to Imam Khomeini Hospital in Tehran, Iran. Methods: This is a cross sectional study regarding side effects of Highly Active Antiretroviral Therapy (HAART) in HIV positive patients referred to Voluntary Counseling and Testing (VCT) center in Imam Khomeini Hospital of Tehran, Iran during a period of the year 2009 to 2010. Two hundred patients under antiretroviral treatment evaluated for the side effects of drug based on available records, face to face interviews and written lab data. Results: Data was collected from a sample of 200 HIV positive patients (72 male). Injection drug use was the most common route of HIV transmission. Co-Infections with Hepatitis C virus (HCV) found in the majority of patients (60.5). Tuberculosis was the most prevalent opportunistic infection. One hundred eighty eight (94) patients experienced at least one adverse drug reaction. The most frequent clinical and paraclinical findings were skin rash (28) and abnormal liver function tests (36). Conclusion: Given the high prevalence of adverse drug reactions among HIV positive patients taking antiretroviral therapy (ART) in this study, clinicians should be aware of ADRs at the initiation of ART as complications can affect patients' adherence to the therapy.