Design by intravenous injection in the Syrian hamster

摘要

When testing the safety of novel pharmaceuticals at Envigo we often need to administer materials intravenously to replicate the intended therapeutic route. This is routine in rats and mice using the tail vein. Recently a customer asked us to use thisroute to administer their test material to hamsters as other rodent models were not suitable for this compound. Clearly the tail was not an option. In this poster we explore the development and refinement of intravenous dosing in the Syrian hamster via the jugular vein and explain our current method and equipment.