Phenotypes and characteristics of the Pole4 mice: an exploration into what makes these animals unique

摘要

Pole4 were an integral component of research at the Cancer Research UK laboratories. Pole4 (DNA Polymerase Epsilon 4, Accessory Subunit) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and DNA-directed DNA polymerase activity.Their origins arise from a hybrid C57BL/6 background and the majority of animals looked like a typical, laboratory mouse. They were commonly crossed with various other strains within the colony with no issues. However, occasionally, they did develop rather strange physical characteristics. These changes affected various parts of the animal's body.