Microwave-assisted synthesis of 1,2,4- triazolo[4,3-a] [1,8]naphthyridines using FeCl3.6H2O under solvent-free conditions

摘要

An efficient and convenient method for the synthesis of 9-aryl-6-(3-fluorophenyl)-1,2,4-triazolo[4,3-a][1,8]naph-thyridines 8 from aryl aldehyde 3-(3-fluorophenyl)-1,8-naphthyridin-2-ylhydrazones 7 using FeCl3.6H2O under microwave irradiation is described. The yields are very good and purity is high. The structural assignments to these compounds are based on their spectral (IR, ~1H NMR and MS) and analytical data.