Further Studies on the Red Cell Glycolipids of Various Breeds of Dogs. A Possible Assumption about the Origin of Japanese Dogs1

摘要

Genetic polymorphism was observed in the sialic acid species constituting the terminal sugar residues of hematosides from dog erythrocytes. One wasN-acetyl-neuraminic acid and the other phenotype wasN-glycolylneuraminic acid, regulated by an autosomal dominant allele (Yasue, S., Handa, S., Miyagawa, S., Inoue, J., Hasegawa, A.,Yamakawa, T. (1978)J. Biochem.83, 1101–1107). In this study we analyzed blood samples from 1, 591 dogs of 36 breeds and demonstrated that the expression ofN-glycolylneuraminic acid was limited to several breeds of oriental dogs in spite of its dominant nature. Moreover, the incidence ofN-glycolylneu-raminic acid was higher in native breeds of northern China, Korea and the southern part of Japan than in other oriental breeds. On the other hand, the Hokkaido-dog is unique in not expressingN-glycolylneuraminic acid. These results suggest that the native breeds in the southern part of Japan came from northern Chinaviathe Korean peninsula in contrast with indigenous breeds of the northern part of Japa