In the course of a study of chemical evolution in the primeval sea, a novel reaction of carbonyl compounds with ammonia was found. Glyoxylic acid reacted with ammonia to affordN-oxalylglycine, which gave glycine in a 3–20yield after 6 n HC1 hydrolysis. Similarly, glyoxylic acid was treated with methylamine to giveN-oxalylsarcosine, which afforded sarcosine in a 9–12yield upon hydrolysis. Pyruvic acid reacted with ammonia to giveN-acetylalanine, which gave alanine in a 1–4yield upon hydrolysis. These reactions provide a novel and facile route to a-amino acids and their derivatives. A mechanism for the reactions is pro
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