The beneficial effects of statin therapy may not apply to all forms of crescentic glomerulonephritis.

摘要

We read with interest the manuscript by Fujita et al describing the effect of statin treatment on experimental anti-glomerular basement membrane glomerulonephritis (anti-GBM GN) in WKY rats. In their elegant study, they showed that atorvastatin (20 mg/kg/day p.o.) given three days pre-induction of GN and for up to 10 days markedly reduced the degree of renal injury. They attributed this to reduction in pro-inflammatory M1 macrophages and increase in anti-inflammatory M2 macrophages. The authors propose a therapeutic application for statins in severe glomerulonephritis.